Multisystem Trajectories Over the Adult Life Course and Relations to Cardiovascular Disease and Death.

ABSTRACT:

Background

Comprehensive conjoint characterization of long-term trajectories representing several biological systems is lacking.

Methods

We measured serially indicators representing 14 distinct biological systems in up to 3,453 participants attending four Framingham Study examinations: bone mineral density, body mass index (BMI), C-reactive protein, glomerular filtration rate, forced vital capacity (FVC), 1 second forced expiratory volume/FVC ratio (FEV1/FVC), gait speed, grip strength, glycosylated hemoglobin (HbA1c), heart rate, left ventricular mass, Mini-Mental State Examination (MMSE), pulse pressure, and total/high-density lipoprotein cholesterol ratio (TC/HDL).

Results

We observed that correlations among the 14 sex-specific trajectories were modest (r < .30 for

SUBMITTER: Niiranen TJ 

PROVIDER: S-EPMC7357457 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature