ABC Transporter DerAB of Lactobacillus casei Mediates Resistance against Insect-Derived Defensins.

ABSTRACT: Bce-like systems mediate resistance against antimicrobial peptides in Firmicutes bacteria. Lactobacillus casei BL23 encodes an "orphan" ABC transporter that, based on homology to BceAB-like systems, was proposed to contribute to antimicrobial peptide resistance. A mutant lacking the permease subunit was tested for sensitivity against a collection of peptides derived from bacteria, fungi, insects, and humans. Our results show that the transporter specifically conferred resistance against insect-derived cysteine-stabilized αβ defensins, and it was therefore renamed DerAB for defensin resistance ABC transporter. Surprisingly, cells lacking DerAB showed a marked increase in resistance against the lantibiotic nisin. This could be explained by significantly increased

SUBMITTER: Revilla-Guarinos A 

PROVIDER: S-EPMC7357469 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature