Short- and Long-Term Transcriptomic Responses of Escherichia coli to Biocides: a Systems Analysis.

ABSTRACT: The mechanisms of the bacterial response to biocides are poorly understood, despite their broad application. To identify the genetic basis and pathways implicated in the biocide stress response, we exposed Escherichia coli populations to 10 ubiquitous biocides. By comparing the transcriptional responses between a short-term exposure (30 min) and a long-term exposure (8 to 12 h) to biocide stress, we established the common gene and pathway clusters that are implicated in general and biocide-specific stress responses. Our analysis revealed a temporal choreography, starting from the upregulation of chaperones to the subsequent repression of motility and chemotaxis pathways and the induction of an anaerobic pool of enzymes and biofilm regulators. A systematic analysis of the transcripti

SUBMITTER: Merchel Piovesan Pereira B 

PROVIDER: S-EPMC7357472 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature