Antimicrobial Peptide GH12 Prevents Dental Caries by Regulating Dental Plaque Microbiota.

ABSTRACT: Due to the complex microecology and microenvironment of dental plaque, novel caries prevention strategies require modulating the microbial communities ecologically and reducing the cariogenic properties effectively. Antimicrobial peptide GH12 reduced the lactic acid production and exopolysaccharide (EPS) synthesis of a Streptococcus mutans biofilm and a three-species biofilm in vitro in previous studies. However, the anticaries effects and microecological effects of GH12 remained to be investigated in a complex biofilm model in vitro and an animal caries model in vivo In the present study, GH12 at 64 mg/liter showed the most effective inhibition of lactic acid production, EPS synthesis, pH decline, and biofilm integrity of human dental plaque-derived multispecies biofilms in vitro, and GH1

SUBMITTER: Jiang W 

PROVIDER: S-EPMC7357485 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature