Cellular heterogeneity map of diverse immune and stromal phenotypes within breast tumor microenvironment.

ABSTRACT:

Background

Cellular heterogeneity within the tumor microenvironment is essential to tumorigenesis and tumor development. A high-resolution global view of the tumor-infiltrating immune and stromal cells in breast tumors is needed.

Methods

xCell was used to create a cellular heterogeneity map of 64 cell types in 1,092 breast tumor and adjacent normal tissues. xCell digitally dissects tissue cellular heterogeneity based on gene expression. Integrated statistical analyses were then performed.

Results

There were noticeable differences between the cell fractions in tumor tissues and normal tissues. Tumors displayed higher proportions of immune cells, including CD4+ Tem, CD8+ naïve T cells, and CD8+ Tcm compared with normal tissues. Immune inhibitory receptors (PD1, CTLA4, L

SUBMITTER: Li Y 

PROVIDER: S-EPMC7357563 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature