Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study.

ABSTRACT:

Background

The importance of systemic inflammation, measured by C-reactive protein, in cognitive decline has been demonstrated; however, the role of vascular inflammation is less understood. Pentraxin 3 (PTX3) is a novel marker of vascular inflammation.

Methods

We followed adults 65 and older, free of cardiovascular disease (CVD) for up to 9 years (n = 1,547) in the Cardiovascular Health Study. We evaluated the relationship between PTX3 and change in cognitive function, measured using the Modified Mini-Mental State Examination (3MSE), and incident cognitive impairment (3MSE < 80). Mediation by CVD events, and effect modification by sex and apolipoprotein E ɛ4 allele (APOE4) were also examined.

Results

The average decline in 3MSE was 0.77 points per year. The associati

SUBMITTER: Miller LM 

PROVIDER: S-EPMC7357589 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature