Aggresome-Like Formation Promotes Resistance to Proteotoxicity in Cells from Long-Lived Species.

ABSTRACT: The capacity of cells to maintain proteostasis declines with age, causing rapid accumulation of damaged proteins and protein aggregates, which plays an important role in age-related disease etiology. While our group and others have identified that proteostasis is enhanced in long-lived species, there are no data on whether this leads to better resistance to proteotoxicity. We compared the sensitivity of cells from long- (naked mole rat [NMR]) and short- (Mouse) lived species to proteotoxicity, by measuring the survival of fibroblasts under polyglutamine (polyQ) toxicity, a well-established model of protein aggregation. Additionally, to evaluate the contribution of proteostatic mechanisms to proteotoxicity resistance, we down-regulated a key protein of each mechanism (autophagy-ATG5; ubiqui

SUBMITTER: Sunchu B 

PROVIDER: S-EPMC7357592 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature