π-Cation Interactions in Molecular Recognition: Perspectives on Pharmaceuticals and Pesticides.

ABSTRACT: The π-cation interaction that differs from the cation-π interaction is a valuable concept in molecular design of pharmaceuticals and pesticides. In this Perspective we present an up-to-date review (from 1995 to 2017) on bioactive molecules involving π-cation interactions with the recognition site, and categorize into systems of inhibitor-enzyme, ligand-receptor, ligand-transporter, and hapten-antibody. The concept of π-cation interactions offers use of π systems in a small molecule to enhance the binding affinity, specificity, selectivity, lipophilicity, bioavailability, and metabolic stability, which are physiochemical features desired for drugs and pesticides.

SUBMITTER: Liang Z 

PROVIDER: S-EPMC7357627 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature