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The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2.

ABSTRACT: The mapping of SARS-CoV-2 human protein-protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host-virus interface of SARS-CoV-2 to enable cancer biologists to apply their knowledge for rapid drug repurposing to treat COVID-19, and help inform the response to potential long-term complications of the disease.

SUBMITTER: Tutuncuoglu B

PROVIDER: S-EPMC7357668 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2.

Tutuncuoglu Beril B Cakir Merve M Batra Jyoti J Bouhaddou Mehdi M Eckhardt Manon M Gordon David E DE Krogan Nevan J NJ

Cancer discovery 20200522 7

The mapping of SARS-CoV-2 human protein-protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host-virus interface of SARS-CoV-2 to enable cancer biologists to apply their knowledge for rapid drug repurposing to treat COVID-19, and help inform the response to potential long-term complications of the disease. ...[more]

PMID: 32444466

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2023-08-20 | GSE189706 | GEO

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