Midbrain Dopaminergic Neuron Development at the Single Cell Level: In vivo and in Stem Cells.

ABSTRACT: Parkinson's disease (PD) is a progressive neurodegenerative disorder that predominantly affects dopaminergic (DA) neurons of the substantia nigra. Current treatment options for PD are symptomatic and typically involve the replacement of DA neurotransmission by DA drugs, which relieve the patients of some of their motor symptoms. However, by the time of diagnosis, patients have already lost about 70% of their substantia nigra DA neurons and these drugs offer only temporary relief. Therefore, cell replacement therapy has garnered much interest as a potential treatment option for PD. Early studies using human fetal tissue for transplantation in PD patients provided proof of principle for cell replacement therapy, but they also highlighted the ethical and practical difficulties associated with

SUBMITTER: Asgrimsdottir ES 

PROVIDER: S-EPMC7357704 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature