A between-herd data-driven stochastic model to explore the spatio-temporal spread of hepatitis E virus in the French pig production network.

ABSTRACT: Hepatitis E virus is a zoonotic pathogen for which pigs are recognized as the major reservoir in industrialised countries. A multiscale model was developed to assess the HEV transmission and persistence pattern in the pig production sector through an integrative approach taking into account within-farm dynamics and animal movements based on actual data. Within-farm dynamics included both demographic and epidemiological processes. Direct contact and environmental transmission routes were considered along with the possible co-infection with immunomodulating viruses (IMVs) known to modify HEV infection dynamics. Movements were limited to 3,017 herds forming the largest community on the swine commercial network in France and data from the national pig movement database were used to build the c

SUBMITTER: Salines M 

PROVIDER: S-EPMC7357762 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature