Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution.

ABSTRACT: At birth, the lungs rapidly transition from a pathogen-free, hypoxic environment to a pathogen-rich, rhythmically distended air-liquid interface. Although many studies have focused on the adult lung, the perinatal lung remains unexplored. Here, we present an atlas of the murine lung immune compartment during early postnatal development. We show that the late embryonic lung is dominated by specialized proliferative macrophages with a surprising physical interaction with the developing vasculature. These macrophages disappear after birth and are replaced by a dynamic mixture of macrophage subtypes, dendritic cells, granulocytes, and lymphocytes. Detailed characterization of macrophage diversity revealed an orchestration of distinct subpopulations across postnatal development to fill context-

SUBMITTER: Domingo-Gonzalez R 

PROVIDER: S-EPMC7358008 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature