Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates.

ABSTRACT:

Background

To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypothesis that infants with transient tachypnea of the newborn (TTN) have higher resistance (R) and lower reactance (X) on day 1.

Methods

Healthy term infants (n = 138) and infants with TTN (n = 17) were evaluated on postnatal days 1 through 3 (NCT03346343). FOT was measured with a mask using a TremoFlo C-100 Airwave System™. R, X, and area under the reactance curve (AX) were measured at prime frequencies 7-41 Hz for 8 s.

Results

In all, 86% of control infants had adequate measurements (coherence >0.8, CV < 0.25) on day 1. Infants with TTN had higher resistance at 13 Hz (TTN 32.5 cm H₂O·s/L [95% CI 25.5-39.4]; controls 23.8 cm H

SUBMITTER: Klinger AP 

PROVIDER: S-EPMC7358118 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature