Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.

ABSTRACT: Complex inflammatory signalling cascades define the response to tissue injury but also control development and homeostasis, limiting the potential for these pathways to be targeted therapeutically. Primary cilia are subcellular regulators of cellular signalling, controlling how signalling is organized, encoded and, in some instances, driving or influencing pathogenesis. Our previous research revealed that disruption of ciliary intraflagellar transport (IFT), altered the cell response to IL-1β, supporting a putative link emerging between cilia and inflammation. Here, we show that IFT88 depletion affects specific cytokine-regulated behaviours, changing cytosolic NFκB translocation dynamics but leaving MAPK signalling unaffected. RNA-seq analysis indicates that IFT88 regulates one third of th

SUBMITTER: Mc Fie M 

PROVIDER: S-EPMC7358134 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature