Integrative Genomic Analysis Predicts Regulatory Role of N ⁶-Methyladenosine-Associated SNPs for Adiposity.

ABSTRACT: Genome-wide association studies have identified many susceptible loci to explore the genetic factors of adiposity. However, the specific mechanisms by which these SNPs (single nucleotide polymorphism), particularly in the non-coding region, are involved in the pathogenesis of adiposity remain unclear. Recently, genetic variation is thought to affect N ⁶-methyladenosine (m6A) RNA modification, which is the most common post-transcriptional messenger RNA modification. In this study, we identified a large number of BMI (body mass index)-associated m6A-SNPs from published GWAS summary statistics through a public database and explored their potential mechanisms involved in the pathogenesis of adiposity. In summary, the integrative analysis detected 20,993 BMI-associated m6A-SNP

SUBMITTER: Lin W 

PROVIDER: S-EPMC7358408 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature