Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia.

ABSTRACT: Amyotrophic lateral sclerosis and frontotemporal dementia are two progressive, adult onset neurodegenerative diseases, caused by the cell death of motor neurons in the motor cortex and spinal cord and cortical neurons in the frontal and temporal lobes, respectively. Whilst these have previously appeared to be quite distinct disorders, in terms of areas affected and clinical symptoms, identification of cognitive dysfunction as a component of amyotrophic lateral sclerosis (ALS), with some patients presenting with both ALS and FTD, overlapping features of neuropathology and the ongoing discoveries that a significant proportion of the genes underlying the familial forms of the disease are the same, has led to ALS and FTD being described as a disease spectrum. Many of these genes encode protein

SUBMITTER: Ranganathan R 

PROVIDER: S-EPMC7358438 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature