Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy.

ABSTRACT: During the development of antimicrobial peptides (AMP) as potential therapeutics, antimicrobial susceptibility testing (AST) stands as an essential part of the process in identification and optimisation of candidate AMP. Standard methods for AST, developed almost 60 years ago for testing conventional antibiotics, are not necessarily fit for purpose when it comes to determining the susceptibility of microorganisms to AMP. Without careful consideration of the parameters comprising AST there is a risk of failing to identify novel antimicrobials at a time when antimicrobial resistance (AMR) is leading the planet toward a post-antibiotic era. More physiologically/clinically relevant AST will allow better determination of the preclinical activity of drug candidates and allow the identification o

SUBMITTER: Mercer DK 

PROVIDER: S-EPMC7358464 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature