Sex Differences in Circulating T-Tau Trajectories After Sports-Concussion and Correlation With Outcome.

ABSTRACT: Sex differences in molecular biomarkers after sports-related concussion (SRC) could steadily advance our understanding of injury heterogeneity and complexity, and help capture phenotypic characteristics, by unveiling sex-dependent pathobiological processes and disease mechanisms. Such knowledge will help improve diagnosis, clinical management, and prognosis. Total-tau (t-tau) has recently emerged as a promising blood marker showing sex-associated differences in neurodegenerative diseases. Nonetheless, to date, little is known about the potential influence of sex on its injury-related concentration and dynamics after SRC. We hypothesized that measurements of circulating levels of t-tau over time would reflect a differential vulnerability signature, providing insights into the sex-related ph

SUBMITTER: Mondello S 

PROVIDER: S-EPMC7358531 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature