Preventive Allergen-Specific Vaccination Against Allergy: Mission Possible?

ABSTRACT: Vaccines for infectious diseases have improved the life of the human species in a tremendous manner. The principle of vaccination is to establish de novo adaptive immune response consisting of antibody and T cell responses against pathogens which should defend the vaccinated person against future challenge with the culprit pathogen. The situation is completely different for immunoglobulin E (IgE)-associated allergy, an immunologically-mediated hypersensitivity which is already characterized by increased IgE antibody levels and T cell responses against per se innocuous antigens (i.e., allergens). Thus, allergic patients suffer from a deviated hyper-immunity against allergens leading to inflammation upon allergen contact. Paradoxically, vaccination with allergens, termed allerg

SUBMITTER: Tulaeva I 

PROVIDER: S-EPMC7358538 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature