Insight into vitronectin structural evolution on material surface chemistries: The mediation for cell adhesion.

ABSTRACT: Biomaterial surface chemistry engenders profound consequences on cell adhesion and the ultimate tissue response by adsorbing proteins from extracellular matrix, where vitronectin (Vn) is involved as one of the crucial mediator proteins. Deciphering the adsorption behaviors of Vn in molecular scale provides a useful account of how to design biomaterial surfaces. But the details of structural dynamics and consequential biological effect remain elusive. Herein, both experimental and computational approaches were applied to delineate the conformational and orientational evolution of Vn during adsorption onto self-assembled monolayers (SAMs) terminating with -COOH, -NH₂, -CH₃ and -OH. To unravel the interplay between cell binding and the charge and wettability of material

SUBMITTER: Li T 

PROVIDER: S-EPMC7358734 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature