Clinically significant incidental QTc prolongation is subject to within-individual variability.

ABSTRACT:

Background

Prolonged QTc interval observed in daily practice is often deemed to be drug induced and might result in drug discontinuation, with possible therapeutic consequences. However, whether clinically significant prolonged QTc may be due to within-individual variability occurs has yet to be described.

Methods

A retrospective cohort study documenting within-individual QTc variability in subjects attending annual routine medical evaluation. At each visit, QT interval was measured and corrected for heart rate using Bazett and three other commonly used formulae. Outcome measures were rates of ΔQTc ≥60 msec, absolute QTc ≥500 msec and QTc ≥25% from baseline.

Results

A total of 188 subjects [54 (29%)] females were recruited. Mean age at first ECG was 54 ± 12.8 years wi

SUBMITTER: Gueta I 

PROVIDER: S-EPMC7358820 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature