Association of Influenza Activity and Environmental Conditions With the Risk of Invasive Pneumococcal Disease.

ABSTRACT:

Importance

Streptococcus pneumoniae is the most commonly identified cause of bacterial pneumonia, and invasive pneumococcal disease (IPD) has a high case fatality rate. The wintertime coseasonality of influenza and IPD in temperate countries has suggested that pathogen-pathogen interaction or environmental conditions may contribute to IPD risk.

Objectives

To evaluate the short-term associations of influenza activity and environmental exposures with IPD risk in temperate countries and to examine the generalizability of such associations across multiple jurisdictions.

Design, setting, and participants

This case-crossover analysis of 19 566 individuals with IPD from 1998 to 2011 combined individual-level outcomes of IPD and population-level exposures. Participants lived

SUBMITTER: Berry I 

PROVIDER: S-EPMC7358913 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature