Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis.

ABSTRACT:

Background

Necrotizing Enterocolitis (NEC) is a major cause of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence of NEC has not been systematically evaluated. We conducted a systematic review and meta-analysis of cohort studies reporting the incidence of NEC in infants with Very Low Birth Weight (VLBW).

Methods

The databases searched included PubMed, MEDLINE, the Cochrane Library, EMBASE and grey literature. Eligible studies were cohort or population-based studies of newborns including registry data reporting incidence of NEC. Incidence were pooled using Random Effect Models (REM), in the presence of substantial heterogeneity. Additional, bias adjusted Quality Effect Models (QEM) were used to get sensitivity estimates. Subgroup anal

SUBMITTER: Alsaied A 

PROVIDER: S-EPMC7359006 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature