Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis.

ABSTRACT:

Background

Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with the severity of acute pancreatitis (AP).

Methods

We retrospectively collected data on patients diagnosed with AP in a tertiary center from 01 January 2014 to 31 December 2016. The highest TBA value during the first 1,2,3,5,7 days after admission was determined as D1, D2, D3, D5, D7 TBA_max. Patients were divided into the high TBA (HTBA) group and the normal TBA (NTBA) group according to whether the TBA_max was ≥10 μmol/L. The prognosis and complications, including death, organ failure (OF) and pancreatic necrosis, were compared between the

SUBMITTER: Xie X 

PROVIDER: S-EPMC7359019 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature