Opportunistic detection of Fusobacterium nucleatum as a marker for the early gut microbial dysbiosis.

ABSTRACT:

Background

The essential roles of gut microbiome have been emphasized in modulating human health and disease. Fusobacterium nucleatum (F. nucleatum), an obligate Gram-negative microorganism residing in oral cavity, gastrointestinal tract and elsewhere, has been recently considered as a potential oncobacterium associated with human cancers. However, the consequence of its enrichment was not extensively explored in terms of microbial homeostasis and stability at the early stage of disease development.

Result

Our analysis on longitudinal metagenomic data generated by the Integrative Human Microbiome Project (iHMP) showed that F. nucleatum was frequently found in inflammatory bowel diseases (IBD) subjects with reduced microbial diversity. Using non-parametric logarithmic linear

SUBMITTER: Huh JW 

PROVIDER: S-EPMC7359021 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature