Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer's disease.

ABSTRACT:

Objective

To determine the inflammatory analytes that predict clinical progression and evaluate their performance against biomarkers of neurodegeneration.

Methods

A longitudinal study of MCI-AD patients in a Discovery cohort over 15 months, with replication in the Alzheimer's Disease Neuroimaging Initiative (ADNI) MCI cohort over 36 months. Fifty-three inflammatory analytes were measured in the CSF and plasma with a RBM multiplex analyte platform. Inflammatory analytes that predict clinical progression on Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB) and Mini Mental State Exam scores were assessed in multivariate regression models. To provide context, key analyte results in ADNI were compared against biomarkers of neurodegeneration, hippocampal volume, and CSF neurofi

SUBMITTER: Pillai JA 

PROVIDER: S-EPMC7359114 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature