Radiobiological and dosimetric assessment of DNA-intercalated ^99mTc-complexes bearing acridine orange derivatives.

ABSTRACT:

Background

Recently, a new family of ^99mTc(I)-tricarbonyl complexes bearing an acridine orange (AO) DNA targeting unit and different linkers between the Auger emitter (^99mTc) and the AO moiety was evaluated for Auger therapy. Among them, ^99mTc-C₃ places the corresponding radionuclide at a shortest distance to DNA and produces important double strand breaks (DSB) yields in plasmid DNA providing the first evidence that ^99mTc can efficiently induce DNA damage when well positioned to the double helix. Here in, we have extended the studies to human prostate cancer PC3 cells using the ^99mTc-C₃ and ^99mTc-C₅ complexes, aiming to assess how the distance to DNA influences the radiation-induced

SUBMITTER: Belchior A 

PROVIDER: S-EPMC7359215 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature