Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs.

ABSTRACT:

Background

Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been characterized as two characteristics of senescent cells; however, whether mTORC1 pathway interacts with heterochromatin organization and contributes to MSC senescence remains unknown. In this study, we investigated the interaction between heterochromatin organization and mTORC1/p70S6K pathway in stress-induced MSC senescence.

Methods

The stress-induced senescence models were established in human umbilical cord-derived MSCs by doxorubicin (Dox) or H₂O₂. Cellular senescence was evaluated by β-Gal activity, upregulation of cell cycle suppress

SUBMITTER: Liu H 

PROVIDER: S-EPMC7359252 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature