Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.

ABSTRACT:

Background

Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of immune system, which is recently concerned as a significant factor for increased risk of various morbidities. Nevertheless, there are few dates explicating the relevancy of T cell senescence to mortality. In this study, we prospectively studied the predictive value of T cell senescence for mortality in hemodialysis patients.

Methods

Patients who had been on hemodialysis treatment for at least 6 months were enrolled. T cell senescence determined by differentiation status was evaluated by flow cytometry. Survival outcomes were estimated using the Kaplan-Meier method. Univariate and multivariate analyses were performed to evaluate the prognostic impact of T cell premature aging and ot

SUBMITTER: Xiang F 

PROVIDER: S-EPMC7359274 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature