Immunohistochemical detection of p53 and pp53 Ser³⁹² in canine hemangiomas and hemangiosarcomas located in the skin.

ABSTRACT:

Background

p53 protein is essential for the regulation of cell proliferation. Aberrant accumulation of it usually occurs in cutaneous malignancies. Mutant p53 is detected by immunohistochemistry because it is more stable than the wild-type p53. However, post-translational modifications of p53 in response to ultraviolet radiation are important mechanisms of wild-type p53 stabilization, leading to positive staining in the absence of mutation. The aims were: 1) to analyze the immunohistochemical expression of p53 and phospho-p53 Serine³⁹² in canine skin endothelial tumours; and 2) to determine if any relationship exists between p53 and phospho-p53 Serine³⁹² overexpression and cell proliferation.

Results

p53 and phospho-p53 Serine³⁹² immunolabeli

SUBMITTER: Garcia-Iglesias MJ 

PROVIDER: S-EPMC7359283 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature