Design of a MAPK signalling cascade balances energetic cost versus accuracy of information transmission.

ABSTRACT: Cellular processes are inherently noisy, and the selection for accurate responses in presence of noise has likely shaped signalling networks. Here, we investigate the trade-off between accuracy of information transmission and its energetic cost for a mitogen-activated protein kinase (MAPK) signalling cascade. Our analysis of the pheromone response pathway of budding yeast suggests that dose-dependent induction of the negative transcriptional feedbacks in this network maximizes the information per unit energetic cost, rather than the information transmission capacity itself. We further demonstrate that futile cycling of MAPK phosphorylation and dephosphorylation has a measurable effect on growth fitness, with energy dissipation within the signalling cascade thus likely being subject to evol

SUBMITTER: Anders A 

PROVIDER: S-EPMC7359329 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature