CORAZON: a web server for data normalization and unsupervised clustering based on expression profiles.

ABSTRACT:

Objective

Data normalization and clustering are mandatory steps in gene expression and downstream analyses, respectively. However, user-friendly implementations of these methodologies are available exclusively under expensive licensing agreements, or in stand-alone scripts developed, reflecting on a great obstacle for users with less computational skills.

Results

We developed an online tool called CORAZON (Correlations Analyses Zipper Online), which implements three unsupervised learning methods to cluster gene expression datasets in a friendly environment. It allows the usage of eight gene expression normalization/transformation methodologies and the attribute's influence. The normalizations requiring the gene length only could be performed to RNA-seq, meanwhile the others

SUBMITTER: Ramos TAR 

PROVIDER: S-EPMC7359491 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature