Prognostic value of an autophagy-related gene expression signature for endometrial cancer patients.

ABSTRACT:

Background

Autophagy is associated with cancer development. Autophagy-related genes play significant roles in endometrial cancer (EC), a major gynecological malignancy worldwide, but little was known about their value as prognostic markers. Here we evaluated the value of a prognostic signature based on autophagy-related genes for EC.

Methods

First, various autophagy-related genes were obtained via the Human Autophagy Database and their expression profiles were downloaded from The Cancer Genome Atlas. Second, key prognostic autophagy-related genes were identified via univariate, LASSO and multivariate Cox regression analyses. Finally, a risk score to predict the prognosis of EC was calculated and validated by using the test and the entire data sets. Besides, the key genes mRN

SUBMITTER: Wang H 

PROVIDER: S-EPMC7359499 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature