Quantitative ¹⁶⁶Ho-microspheres SPECT derived from a dual-isotope acquisition with ^99mTc-colloid is clinically feasible.

ABSTRACT:

Purpose

Accurate dosimetry is essential in radioembolization. To this purpose, an automatic protocol for healthy liver dosimetry based on dual isotope (DI) SPECT imaging, combining holmium-166 (¹⁶⁶Ho)-microspheres, and technetium-99 m (^99mTc)-colloid was developed: ¹⁶⁶Ho-microspheres used as scout and therapeutic particles, and ^99mTc-colloid to identify the healthy liver. DI SPECT allows for an automatic and accurate estimation of absorbed doses, introducing true personalized dosimetry. However, photon crosstalk between isotopes can compromise image quality. This study investigates the effect of ^99mTc downscatter on ¹⁶⁶Ho dosimetry, by comparing ¹⁶⁶Ho-SPECT reconstructions of patient scans acquired before

SUBMITTER: Stella M 

PROVIDER: S-EPMC7359973 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature