The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics.

ABSTRACT: Cancer pharmacogenomics is the science concerned with understanding genetic alterations and its effects on the pharmacokinetics and pharmacodynamics of anti-cancer drugs, with the aim to provide cancer patients with the precise medication that will achieve a good response and cause low/no incidence of adverse events. Advances in biotechnology and bioinformatics have enabled genomic research to evolve from the evaluation of alterations at the single-gene level to studies on the whole-genome scale using large-scale genotyping and next generation sequencing techniques. International collaborative efforts have resulted in the construction of databases to curate the identified genetic alterations that are clinically significant, and these are currently utilized in clinical sequencing and liquid

SUBMITTER: Chan HT 

PROVIDER: S-EPMC7359987 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature