Respiratory Syncytial Virus-related Death in Children With Down Syndrome: The RSV GOLD Study.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is a major cause of mortality in children younger than 5 years worldwide. Systematic reviews have shown that Down syndrome (DS) is an independent risk factor for severe RSV infection. We aimed to describe demographic and clinical characteristics of children with DS who died with RSV infection.

Methods

We performed a retrospective case series in which data were shared by individual researchers, research networks and physicians worldwide as part of the RSV Global Online Database study. We included children with DS who died when younger than 5 years of age with laboratory-confirmed RSV infection.

Results

We included 53 children with DS and RSV-related mortality from 20 countries in 5 continents. Five (9.4%) children were from

SUBMITTER: Lowensteyn YN 

PROVIDER: S-EPMC7360096 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature