Borderline Personality Traits Are Not Correlated With Brain Structure in Two Large Samples.

ABSTRACT:

Background

Borderline personality disorder is associated with severe psychiatric presentations and has been linked to variability in brain structure. Dimensional models of borderline personality traits (BPTs) have become influential; however, associations between BPTs and brain structure remain poorly understood.

Methods

We tested whether BPTs are associated with regional cortical thickness, cortical surface area, and subcortical volumes (n = 152 brain structure metrics) in data from the Duke Neurogenetics Study (n = 1299) and Human Connectome Project (n = 1099). Positive control analyses tested whether BPTs are associated with related behaviors (e.g., suicidal thoughts and behaviors, psychiatric diagnoses) and experiences (e.g., adverse childhood experiences).

Results

SUBMITTER: Baranger DAA 

PROVIDER: S-EPMC7360105 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature