Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases?

ABSTRACT:

Background

COVID-19, a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), commonly presents as fever, cough, dyspnea, and myalgia or fatigue. Although the majority of patients with COVID-19 have mild symptoms, some are more prone to serious outcomes, including pneumonia, acute respiratory distress syndrome (ARDS), and even death. Hemophagocytic lymphohistiocytosis (HLH) is a severe, life-threatening inflammatory syndrome associated with intense cytokine release (also known as a "cytokine storm"). Similar to COVID-19, HLH is characterized by aggressive course leading to multi-organ failure.

Main text

The purpose of this review article is to draw attention to the possibility of the complication of HLH in patients with the severe course of COVID

SUBMITTER: Opoka-Winiarska V 

PROVIDER: S-EPMC7360379 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature