Region-specific mechanisms of corticosteroid-mediated inotropy in rat cardiomyocytes.

ABSTRACT: Regional differences in ion channel activity in the heart control the sequence of repolarization and may contribute to differences in contraction. Corticosteroids such as aldosterone or corticosterone increase the L-type Ca²⁺ current (I_CaL) in the heart via the mineralocorticoid receptor (MR). Here, we investigate the differential impact of corticosteroid-mediated increase in I_CaL on action potentials (AP), ion currents, intracellular Ca²⁺ handling and contractility in endo- and epicardial myocytes of the rat left ventricle. Dexamethasone led to a similar increase in I_CaL in endocardial and epicardial myocytes, while the K⁺ currents I_to and I_K were unaffected. However, AP duration (APD) and AP-induced C

SUBMITTER: Wacker C 

PROVIDER: S-EPMC7360564 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature