Bioactivity studies of porphyrinoids against microsporidia isolated from honeybees.

ABSTRACT: Microsporidian infections are dangerous to honeybees due to the absence of an efficient treatment for nosemosis. In the present work, the abilities of several porphyrins to directly inactivate microsporidia derived from Nosema-infected honeybees were studied in vitro. Amide derivatives of protoporphyrin IX (PPIX) conjugated with one and two amino acid moieties were synthesized, and their activities were compared with those of two cationic porphyrins, TMePyP and TTMePP. The most active porphyrins, PP[Lys-Asp]₂, PP[Lys-TFA]₂, PP[Asp(ONa)₂]₂ and PP[Lys-Lys]₂ at concentrations as low as 10-50 µM exerted significant effects on microsporidia, reducing the number of spores by 67-80% compared to the control. Live-cell imaging of the spores tre

SUBMITTER: Buczek K 

PROVIDER: S-EPMC7360595 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature