Dataset Information
Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Poisa-Beiro L
PROVIDER: S-EPMC7360735 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells.
Scientific reports 20200714 1
Inspired by recent proteomic data demonstrating the upregulation of carbon and glycogen metabolism in aging human hematopoietic stem and progenitor cells (HPCs, CD34+ cells), this report addresses whether this is caused by elevated glycolysis of the HPCs on a per cell basis, or by a subpopulation that has become more glycolytic. The average glycogen content in individual CD34+ cells from older subjects (> 50 years) was 3.5 times higher and more heterogeneous compared to younger subjects (< 35 ye ...[more]
