Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes.

ABSTRACT: Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma metabolite markers associated with freedom from vascular complications in people with very long duration of type 1 diabetes (T1D). Individuals with T1D, who despite having longer than 30 years of diabetes duration never developed major macro- or microvascular complications (non-progressors; NP) were compared with those who developed vascular complications within 25 years from diabetes onset (rapid progressors; RP) in the Scandinavian PROLONG (n = 385) and DIALONG (n = 71) cohorts. The DIALONG study also included 75 healthy controls. Plasma metabolites were measured using g

SUBMITTER: Jain R 

PROVIDER: S-EPMC7360755 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature