An Unusual MHC Molecule Generates Protective CD8+ T Cell Responses to Chronic Infection.

ABSTRACT: The CD8+ T cell response to the intracellular parasite Toxoplasma gondii varies dramatically between mouse strains, resulting in stark differences in control of the parasite. Protection in BALB/c mice can be attributed to an unusually strong and protective MHC-1 L^d-restricted CD8+ T cell response directed against a peptide derived from the parasite antigen GRA6. The MHC-1 L^d molecule has limited peptide binding compared to conventional MHC molecules such as K^b or D^b, which correlates with polymorphisms associated with "elite control" of HIV in humans. To investigate the link between the unusual MHC-1 molecule L^d and the generation of "elite controller" CD8+ T cell responses, we compared the GRA6-L^d specific T cell res

SUBMITTER: Tsitsiklis A 

PROVIDER: S-EPMC7360836 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature