Inflammation: A bridge between diabetes and COVID-19, and possible management with sitagliptin.

ABSTRACT: Patients with SARS-CoV-2 infections experience lymphopenia and inflammatory cytokine storms in the severe stage of the disease, leading to multi-organ damage. The exact pattern of immune system changes and their condition during the disease process is unclear. The available knowledge has indicated that the NF-kappa-B pathway, which is induced by several mediators, has a significant role in cytokine storm through the various mechanisms. Therefore, identifying the state of the immune cells and the dominant mechanisms for the production of cytokines incorporated in the cytokine storm can be a critical step in the therapeutic approach. On the other hand, some studies identified a higher risk for diabetic patients. Diabetes mellitus exhibits a close association with inflammation and increases t

SUBMITTER: Mozafari N 

PROVIDER: S-EPMC7361050 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature