Ontology highlight
ABSTRACT:
SUBMITTER: Aksoy H
PROVIDER: S-EPMC7361069 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Aksoy Hasan H Karadag Ayse Serap AS Wollina Uwe U
Dermatologic therapy 20200727 6
COVID-19 is an outbreak of viral pneumonia which became a global health crisis, and the risk of morbidity and mortality of people with obesity are higher. SARS-CoV-2, the pathogen of COVID-19, enters into cells through binding to the Angiotensin Converting Enzyme (ACE) homolog-2 (ACE2). ACE2 is a regulator of two contrary pathways in renin angiotensin system (RAS): ACE-Ang-II-AT1R axis and ACE2-Ang 1-7-Mas axis. Viral entry process eventuates in downregulation of ACE2 and subsequent activation o ...[more]