A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients.

ABSTRACT: We analysed data from 80 patients who tested positive for SARS-CoV-2 RNA who had previously been HLA typed to support transplantation. Data were combined from two adjacent centres in Manchester and Leeds to achieve a sufficient number for early analysis. HLA frequencies observed were compared against two control populations: first, against published frequencies in a UK deceased donor population (n = 10,000) representing the target population of the virus, and second, using a cohort of individuals from the combined transplant waiting lists of both centres (n = 308), representing a comparator group of unaffected individuals of the same demographic. We report a significant HLA association with HLA- DQB1*06 (53% vs. 36%; p < .012; OR 1.96; 95% CI 1.94-3.22) and infection. A bias towards an inc

SUBMITTER: Poulton K 

PROVIDER: S-EPMC7361549 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature