Determinants of Cross-Sectional and Longitudinal Health-Related Quality of Life in Memory Clinic Patients Without Dementia.

ABSTRACT:

Objective

To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia.

Methods

This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 ± 8.6, 64.4% males, Mini-Mental State Examination score 26.9 ± 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS).

Results

Mean HRQoL at study entry was 69.4 ± 15.6. The presence of agitation, appetite and eating abnormalities,

SUBMITTER: Banning LCP 

PROVIDER: S-EPMC7361660 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature