Use of Anakinra to Prevent Mechanical Ventilation in Severe COVID-19: A Case Series.

ABSTRACT:

Objective

To report the clinical experience with anakinra in preventing mechanical ventilation in patients with coronavirus disease 2019 (COVID-19), symptoms of cytokine storm syndrome, and acute hypoxemic respiratory failure.

Methods

To be included in this retrospective case series, patients must have had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), fever, ferritin levels >1,000 ng/ml with 1 additional laboratory marker of hyperinflammation, and acute hypoxemic respiratory failure. Acute hypoxemic respiratory failure was defined as requiring 15 liters of supplemental oxygen via a nonrebreather mask combined with 6-liter nasal cannula or use of ≥95% oxygen by high-flow nasal cannula. We excluded patients in whom there was suspicion of bacterial infection or

SUBMITTER: Navarro-Millan I 

PROVIDER: S-EPMC7361793 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature