DMET^TM Genotyping: Tools for Biomarkers Discovery in the Era of Precision Medicine.

ABSTRACT: The knowledge of genetic variants in genes involved in drug metabolism may be translated into reduction of adverse drug reactions, increase of efficacy, healthcare outcomes improvement and economic benefits. Many high-throughput tools are available for the genotyping of Single Nucleotide Polymorphisms (SNPs) known to be related to drugs and xenobiotics metabolism. DMET^TM platform represents an example of SNPs panel to discover biomarkers correlated to efficacy or toxicity in common and rare diseases. The difficulty in analyzing the mole of information generated by DMET^TM platform led to the development and implementation of algorithms and tools for statistical and data mining analysis. These softwares allow efficient handling of the omics data to validate the explorat

SUBMITTER: Agapito G 

PROVIDER: S-EPMC7362183 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature