Shared mechanisms for cognitive impairment and physical frailty: A model for complex systems.

ABSTRACT:

Introduction

We describe findings from a large study that provide empirical support for the emerging construct of cognitive frailty and put forth a theoretical framework that may advance the future study of complex aging conditions. While cognitive impairment and physical frailty have long been studied as separate constructs, recent studies suggest they share common etiologies. We aimed to create a population predictive model to gain an understanding of the underlying biological mechanisms for the relationship between physical frailty and cognitive impairment.

Methods

Data were obtained from the longitudinal "Invecchaiare in Chianti" (Aging in Chianti, InCHIANTI Study) with a representative sample (n = 1453) of older adults from two small towns in Tuscany, Italy. Our

SUBMITTER: Sargent L 

PROVIDER: S-EPMC7362211 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature